Common mugwort chrysanthenyl-acetate-CT essential oil (Artemisia vulgaris L., Asteraceae = Compositae family — daisy/sunflower family) is a chrysanthenyl-acetate-DOMINANT aerial-parts-distilled monoterpenic-ester-CT-class EO with TY-EXPLICIT-PREGNANCY-BREASTFEEDING-ALL-ROUTES-CONTRAINDICATED + slight-neurotoxicity-thujone-class hazard signature, T&Y EXPLICIT max dermal use level 9.6%, T&Y EXPLICIT max adult daily oral dose 269 mg, derived from total thujone 2.6% (β-thujone 2.1–2.3% + α-thujone 0.2–0.3%) × thujone limits 0.1 mg/kg + 0.25% per Thujone profile Ch.14. B216 Ch.13 p.702 cites Fakhry private-communication 2003 chemistry: chrysanthenyl acetate 31.7–32.8% (major-dominant) + germacrene D 12.1–15.9% (secondary) + β-caryophyllene 3.8–3.9% + artemisia ketone 0–3.1% + β-selinene 2.8–2.9% + 1,8-cineole 2.2–2.9% + β-thujone 2.1–2.3% + α-selinene 1.5–2.2% + sabinene 1.8–1.9% + santolina triene 0–1.9% + terpinen-4-ol 1.7–1.8% + borneol 1.6–1.7% + α-caryophyllene 1.5–1.6% + caryophyllene oxide 1.2–1.5% + p-cymene 0.9–1.5% + β-myrcene 1.2–1.3% + phytol 0.9–1.2% + spathulenol ~1.2% + α-copaene 1.0–1.1% + α-thujone 0.2–0.3%. Hazard signature B216 EXPLICIT verbatim: "Hazards: Slight neurotoxicity. Contraindications (all routes): Pregnancy, breastfeeding. Maximum adult daily oral dose: 269 mg. Maximum dermal use level: 9.6%." TY-EXPLICIT-DERIVATION-RAIL B216 verbatim: "Our oral and dermal restrictions are based on 2.6% total thujone content with thujone limits of 0.1 mg/kg and 0.25% (see Thujone profile, Chapter 14)." → Total thujone 2.6% × thujone-Ch.14-cap 0.25% dermal = 9.6% max dermal + 2.6% × 0.1 mg/kg × 70 kg adult ÷ 0.026 = 269 mg oral. Neurotoxicity-NOAEL-Margaria-1963 rail B216 EXPLICIT: "There is a risk of convulsions with moderately high doses of thujone. The thujone NOAEL for convulsions was reported to be 10 mg/kg in male rats and 5 mg/kg in females." Acute-toxicity-α-β-thujone-LD50-rail B216 EXPLICIT: "Both α- and β-thujone are moderately toxic, with reported oral LD values ranging from 190–500 mg/kg for different species." Antioxidant + antimutagenic class-rail B216 EXPLICIT (var. indica): "Essential oil of Artemisia vulgaris var. indica strongly scavenged DPPH radicals (Xiufen et al 2004). Artemisia vulgaris var. indica oil was antimutagenic in an assay with S. typhimurium TA98 (Hiramatsu et al 2004)." Comments + species-confusion-rail B216 EXPLICIT verbatim: "We could not establish for certain whether the chrysanthenyl acetate-rich essential oil sold as deriving from Artemisia vulgaris might actually be the chrysanthenyl acetate chemotype of Artemisia herba-alba (see White wormwood, below). Artemisia vulgaris is sometimes erroneously given as the source of white wormwood oil." → CRITICAL species-mislabeling-rail: commercial chrysanthenyl-acetate-CT may actually be A. herba-alba white wormwood with same chrysanthenyl-acetate-CT chemistry — buyer/practitioner accepts source-uncertainty inherent in commercial supply. Cross-CT-Artemisia-vulgaris-disambiguation-rail B216 verbatim comparing this CT (p.702) vs. common camphor/thujone CT (p.701): chrysanthenyl-acetate-CT (this oil — 2.6% total thujone, max dermal 9.6%) ≠ common camphor/thujone-CT (camphor 20.8% + α-thujone 11.4% + 1,8-cineole 9.0% + isoborneol 9.3%, max dermal 2.0%, max oral 56 mg). Same species + 2 commercial chemotypes + radically different caps (9.6% vs 2.0% = 4.8x divergence) + same pregnancy-breastfeeding-contra-rail per thujone-class = canonical Asteraceae-Artemisia-genus chemotype-divergence case. Genus-wide-Artemisia-thujone-class-pregnancy-contra-rail: [[mugwort-vulgaris-chrysanthenyl]] (this oil — 2.6% thujone, max 9.6%) + [[lanyana]] EO755 23b (A. afra α+β-thujone 31.4% max 0.8%) + great mugwort A. arborescens (β-thujone 34% max 0.7% + drug interaction) + [[genipi]] EO732 19b (A. genepi α-thujone 90.2% extreme) + common camphor/thujone-CT A. vulgaris B216 p.701 (max 2.0%) + sage Salvia officinalis + wormwood A. absinthium (NOT distilled commercially per T&Y); class-rail thujone-extreme + GABA-A-antagonist-anticonvulsant-medication-interaction + pregnancy-breastfeeding-CONTRA. Thujone-content-spectrum across Artemisia-genus: 0% (artemisia-vestita thujone-free outlier B216) → 0.5% lower-grade → 2.6% (this oil chrysanthenyl-CT) → 11.4% (camphor/thujone-CT A. vulgaris) → 31.4% (lanyana A. afra) → 34% (great mugwort A. arborescens) → 90.2% (genepi A. genepi) — chemotype-availability-vs-safety mismatch class-rail per B216 EXPLICIT (lanyana, lanyana). Continues Mini-Batch 25b heterogeneity-progression (clean piperitone-oxide-Lamiaceae [[mint-wild-forest]] EO769 → thujone-class-pregnancy-contra Asteraceae chrysanthenyl-CT [this oil] → clean artemisia-ketone-Asteraceae [[mugwort-douglas]] EO771 same-genus-different-CT cross-contrast).
Tổng Quan
- Danh pháp khoa học
- Artemisia vulgaris L.
- Họ thực vật
- Asteraceae
- Bộ phận dùng
- Aerial parts
- Phương pháp chiết xuất
- steam_distillation
- Màu sắc
- —
- Phân loại nốt hương
- Nốt Top/Middle
- Hương thơm
- —
- Chemotype / Cultivar
- —
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Fresh-camphoraceous-floral-acetate, chrysanthenyl-acetate-CT-DOMINANT, slightly-mugwort-thujone-undertone, sesquiterpene-warm-base, slightly-sage-rosemary-camphor-undertone, slightly-eucalyptus-cineole-secondary, Artemisia vulgaris chrysanthenyl-CT character distinct-from-camphor/thujone-CT
Tươi mát long não phụ tầng hoa este, đặc trưng chrysanthenyl acetate CT, hơi ngải cứu thujone phụ tầng, ấm sesquiterpene nền tảng, hơi xô thơm hương thảo long não phụ tầng, hơi bạch đàn cineole phụ tầng, Artemisia vulgaris chemotype chrysanthenyl khác biệt với chemotype long não-thujone đặc trưng
2–4 giờ
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Pha Chế & Hòa Hợp
Sesquiterpene fraction (germacrene D 12.1–15.9%, β-caryophyllene 3.8–3.9%) contributes to DPPH radical scavenging activity demonstrated in A. vulgaris var. indica; class-extrapolated to this CT.
Ref: Xiufen et al 2004 (class-extrapolation from var. indica CT; not this chrysanthenyl-acetate chemotype directly)
Sesquiterpene constituents including germacrene D and β-caryophyllene are associated with antimutagenic protection in Salmonella typhimurium TA98 assay demonstrated in var. indica; class-extrapolated.
Ref: Hiramatsu et al 2004 (class-extrapolation from var. indica CT)
β-Caryophyllene (3.8–3.9%) is a selective CB2 receptor partial agonist modulating NF-κB inflammatory signaling; germacrene D (12.1–15.9%) adds secondary sesquiterpene anti-inflammatory contribution.
Ref: class-extrapolation from B216 β-Caryophyllene profile Chapter 14
β-Caryophyllene (3.8–3.9%) belongs to the anticarcinogenic constituent class explicitly noted by B216; present at research-relevant concentration but constitutes a minor signal in this oil.
Ref: B216 β-Caryophyllene profile Chapter 14 (research context only; not a therapeutic claim)
AI-summary
No RCT-grade clinical trials were located for the chrysanthenyl-acetate CT of Artemisia vulgaris specifically. The strongest available signals come from two in-vitro studies on the closely related var. indica chemotype: Xiufen et al (2004) demonstrated DPPH radical scavenging antioxidant activity, and Hiramatsu et al (2004) showed antimutagenic activity in S. typhimurium TA98 assay. Both represent class-extrapolations only and cannot be attributed directly to this CT. Thujone safety data are anchored by Margaria (1963) NOAEL (convulsions: 10 mg/kg male / 5 mg/kg female rats), underpinning T&Y's pregnancy and breastfeeding all-routes contraindication. B216 p.702 records a triple data-gap (no skin-sensitization, no acute-toxicity, no human clinical data) for this chemotype. Evidence level: in-vitro/class-extrapolation only.
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| Phương pháp | Liều lượng | Ghi chú |
|---|---|---|
| Diffusion | 2–3 drops in 100 ml water (ultrasonic diffuser) | Max 30-min sessions; ventilate room after. Avoid if epilepsy or anticonvulsant medications. Never diffuse around pregnant women, breastfeeding mothers, or infants. |
| Topical massage | 1–3% dilution in carrier oil (adult max 9.6%) | Apply to back, shoulders, or limbs. Strictly contraindicated in pregnancy and breastfeeding (all routes). Patch-test recommended. Avoid with anticonvulsant medications. |
| Personal inhalation | 1–2 drops on tissue or personal inhaler wick | Brief sessions only (≤10 min). Not for children or pregnant/breastfeeding women. Avoid with GABA-A–targeting medications (anticonvulsants, barbiturates). |
| Diluted body serum | 0.5–1% in carrier oil for antioxidant body-care use | Adult use only; avoid sensitive or damaged skin. Contraindicated in pregnancy and breastfeeding. Avoid facial application on reactive skin types. |
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