Tổng Quan
- Danh pháp khoa học
- Sassafras albidum (Nutt.) Nees
- Họ thực vật
- Lauraceae
- Bộ phận dùng
- Wood and/or roots
- Phương pháp chiết xuất
- Steam distillation
- Màu sắc
- —
- Phân loại nốt hương
- Nốt Top/Middle
- Hương thơm
- —
- Chemotype / Cultivar
- —
Các quốc gia sản xuất chính
Tình trạng tại Việt Nam
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sweet, balsamic, spicy, root-beer, anise-adjacent, camphoraceous, slightly licorice, intensely aromatic, warm, resinous, slight nutmeg-undertone, sassafras-iconic
ngọt, nhựa thơm, cay, root-beer-đặc-trưng, gợi hồi, long não nhẹ, thoảng cam thảo, thơm đậm, ấm, nhựa, thoảng nhục đậu khấu, sassafras-mang-tính-biểu-tượng
2–4 giờ
Tên gọi tại Việt Nam
Pha Chế & Hòa Hợp
Safrole-dominant oil was historically applied as a mild counterirritant and flavoring; all such uses are prohibited due to safrole metabolic activation via 1'-hydroxysafrole and 2',3'-epoxysafrole intermediates forming hepatic DNA adducts.
Ref: Tisserand & Young 2014 (B216 p.813-815); US FDA 1960
Safrole (61.7–97%) undergoes CYP2E1/CYP1A2 activation to 1'-hydroxysafrole and 2',3'-epoxysafrole, forming DNA adducts with liver macromolecules producing hepatocellular carcinoma in rats; human relevance supported by structural analogy.
Ref: B216 Chapter 14 — Safrole profile; Abbott et al 1961; Miller 1979
In Cinnamomum rigidissimum-sourced oil, methyleugenol (28.6%) adds a second metabolically-activated carcinogen class; both constituents share epoxide-intermediate DNA-adduct mechanisms producing cumulative hepatic carcinogenicity.
Ref: Zhu et al 1993; B216 Chapter 14 — Methyleugenol profile; IFRA 2009; European Commission 2002
Acute oral LD50 1.9 g/kg rat (S. albidum) and 1.58 g/kg (O. pretiosa); case reports document survival after 4–60 mL ingestion in children with significant CNS and GI toxicity; chronic carcinogenic risk far exceeds the acute hazard threshold.
Ref: Opdyke & Letizia 1982 (RIFM p.825-826); Opdyke 1978 (RIFM p.831); Craig 1953; Grande & Dannewitz 1987
AI-summary
No therapeutic RCTs exist for sassafras essential oil. The oil is classified CONTRAINDICATED ALL ROUTES by Tisserand & Young 2014 due to safrole (61.7–97%), a rodent hepatocarcinogen prohibited as a food additive by US FDA since 1960. Abbott et al (1961) demonstrated hepatocellular carcinoma in rats on 390–1170 ppm dietary safrole/sassafras oil. Miller (1979) reported 95% lethality at 10,000 ppm over 19 days. RIFM patch-test data (Opdyke 1982, Rudzki 1976) show no immediate skin sensitization at low concentrations — but this does not mitigate chronic carcinogenic risk. All historic therapeutic applications (rubefacient, flavoring, tooth-pain analgesic) are superseded by the carcinogenicity classification. CITES listing for Ocotea odorifera is proposed pending per UNEP-WCMC.
NarrativeTâm trạng: Grounding, Stimulating
Chakra
root
Ngũ hành
moc
| Phương pháp | Liều lượng | Ghi chú |
|---|---|---|
| Diffusion — professional research context only | 1–2 drops in well-ventilated space; 5–10 min max; professional use only | For professional research or organoleptic-reference only. NOT for personal aromatherapy or home diffusers. Chronic safrole vapour risk extrapolated from dietary carcinogenicity studies (Abbott 1961). |
| Hazard reference only — not for therapeutic use | N/A — oil must not be applied or ingested under any circumstances | ALL routes contraindicated per Tisserand & Young 2014. US FDA prohibited safrole and sassafras as food additives in 1960. Do NOT apply to skin, ingest, or blend for personal therapeutic use. |
Dầu nền phù hợp
Kết hợp tốt với
Blend kinh điển
An Toàn
Giới hạn da tối đa
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Giới hạn IFRA
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Thai kỳ & Cho con bú
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Bảo quản
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