Jaborandi essential oil (Pilocarpus jaborandi Holmes + Pilocarpus microphyllus Stapf, Rutaceae family — South American leaves steam distillate) is a TWO-CHEMOTYPE limonene+tridecanone-class oil (P. jaborandi: limonene 0–67.1% + 2-tridecanone 18.6–60.7%) OR sesquiterpene-pentadecanone-class oil (P. microphyllus: β-caryophyllene 23.9–40.6% + 2-pentadecanone 14.2–28.1% + 2-tridecanone 2.4–20.4%) with REGULATORY-PROHIBITED + UNCERTAIN-TOXICITY-CAUTION-ALL-ROUTES safety signature. B216 Ch.13 p.630–631 cites Andrade-Neto 2000 (P. jaborandi) + Taveira 2003 (P. microphyllus) chemistry — see chemistry section. Hazard signature: T&Y verbatim "Hazards: May be toxic. Cautions (all routes): Use with caution due to uncertain toxicity." CONTRAINDICATED-ALL-ROUTES via regulatory + uncertain-toxicity rails:
- EU prohibited cosmetic ingredient (jaborandi extracts and oils prohibited as cosmetic ingredients in the EU)
- Canada prohibited cosmetic ingredient (same prohibition)
- UK pharmacy-only since 1968 (jaborandi preparations can only be sold in a pharmacy under the supervision of a pharmacist — UK regulation since 1968)
- Pilocarpine alkaloid plant — Pilocarpus jaborandi leaves contain potentially toxic alkaloids (pilocarpine + isopilocarpine); alkaloids "are not generally found in essential oils" per T&Y, but Burfield (Cropwatch 2011) maintains jaborandi oil contains 0.8% of toxic alkaloids — none reported in cited GC-MS analyses, but ambiguity remains
- 2-Tridecanone + 2-pentadecanone aliphatic-ketone class at high content (combined 38.6–79.5% range) — uncharacterized acute oral + dermal LD50 per T&Y; "no information found"
Mark in DB: contraindicated_all = TRUE; max_dilution_adult = NULL; safety_level = avoid; cap_derivation = do_not_use_regulatory_prohibited_uncertain_toxicity_class. Two chemotypes (P. jaborandi limonene+tridecanone CT vs P. microphyllus β-caryophyllene+pentadecanone CT) but regulatory + safety status applies uniformly across both species + chemotypes — neither is permitted for skincare or cosmetic application in EU + Canada; UK pharmacy-only. Rutaceae family CRITICAL non-citrus subgroup — Rutaceae includes citrus (orange + bergamot + lemon — phototoxic but not contraindicated_all) AND Pilocarpus (CONTRAINDICATED-ALL); class-shared at family level only (Rutaceae) but not at safety level. Uncertain-toxicity peer class with [[boldo]] EO692 15a (T&Y "Do not use" via ascaridole + thujone + sabinyl acetate) + select pyrolysate oils where T&Y signals strict contraindication. Limited commercial production — niche South American supply; primarily research/pharmacy-grade NOT consumer aromatherapy. Forms 22a heterogeneity trio with [[hyacinth]] EO745 (Liliaceae methyleugenol-cap absolute) + [[inula]] EO746 (clean Dittrichia graveolens) — closing position with maximum-hazard signature.