Honeysuckle absolute (Lonicera periclymenum L. + L. caprifolium L. + L. etrusca Santi, Caprifoliaceae family — first Caprifoliaceae entry in Phase 3 mass-ingest SINGLETON family) is a linalool-extreme-dominant + germacrene D + indole + α-farnesene + nerolidol + jasmine lactone floral absolute (NOT steam-distilled essential oil — solvent extraction from flowers) with clean Tisserand & Young profile ("Hazards: None known. Contraindications: None known."). B216 Ch.13 p.621–622 cites Joulain 1986 chemistry: linalool 75.0% + germacrene D 5.8% + indole 3.3% + α-farnesene 3.0% + nerolidol 2.2% + jasmine lactone 1.4% — note T&Y explicit "this is a headspace analysis of L. caprifolium flowers" (chemistry derived from headspace volatile sampling not full GC-MS profile of solvent-extracted absolute). Framework caps default conservative (T&Y patch data: tested at 3% on 25 volunteers — neither irritating nor sensitizing per Ford et al 1988a p.357): adult dermal 5.0% + sensitive 3.0% + pregnancy 5.0% + pediatric cascade + max_oral 700 mg/day. Phototoxicity-NEGATIVE for normal use — minimal phototoxic effects observed only at 100% undiluted concentration; NO phototoxic effects at 50% in benzene or 12.5%/50%/70% in methanol per Ford 1988a — practical-aromatherapy-use phototoxicity NEGATIVE within standard dilution. Linalool-extreme-content rail (75% — among highest in B216): rivals ho-leaf-linalool-CT EO and rosewood; signature floral character driver. Linalool-oxidation-skin-sensitization rail (latent): oxidation products of linalool may be skin sensitizing — IFRA-recommended antioxidant control (0.1% BHT or α-tocopherol per IFRA 2009); fresh absolute clean per Ford patch test, but oxidized linalool is the documented skin-sensitization driver. Mutagenicity asymmetry rail (Ford 1988a): mutagenic to S. typhimurium at 100 mg/mL in water but NOT mutagenic in DMSO and NOT mutagenic in Bacillus subtilis rec-assay — solvent-dependent in-vitro mutagenicity that does NOT translate to clinical safety concern; honeysuckle absolute contains no known carcinogens; linalool + nerolidol display anticarcinogenic activity. Reproductive toxicity NEGATIVE rail: virtual absence of reproductive toxicity for linalool (Politano et al 2008) suggests honeysuckle absolute oil is not hazardous in pregnancy per T&Y verbatim. Caprifoliaceae family SINGLETON in Phase 3 mass-ingest — first oil from honeysuckle family; family heterogeneity rail not yet established (single data point). Limited commercial availability — flower-absolute extraction is niche; per B216 p.622 verbatim "Limited availability." Forms same-batch trio with hinoki-root EO742 + hinoki-wood EO743 demonstrating intra-batch family-and-extraction-method heterogeneity (2× Cupressaceae steam-distillation conifer-tree EOs + 1× Caprifoliaceae solvent-extracted flower-absolute) — all 3 with clean T&Y profile, illustrating that "clean profile" can occur across radically different botanical families + extraction methods + chemotypes.
Tổng Quan
- Danh pháp khoa học
- Lonicera periclymenum L.
- Họ thực vật
- Caprifoliaceae
- Bộ phận dùng
- Flowers
- Phương pháp chiết xuất
- solvent_extraction
- Màu sắc
- —
- Phân loại nốt hương
- Nốt Middle
- Hương thơm
- —
- Chemotype / Cultivar
- —
Các quốc gia sản xuất chính
Tình trạng tại Việt Nam
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Sun-warmed honeysuckle blossoms, narcotic and honey-drenched; creamy linalool softness with a powdery shimmer; jasmine-kissed with a faint animal warmth; lingering as a summer dusk that refuses to cool
Hoa kim ngân tắm nắng ngọt ngào mê mẩn; nhung mềm kem ấm phảng phất phấn hoa; chiều sâu ma mị kiểu hoa nhài; lưu luyến như buổi tối hè không chịu tắt
2–4 giờ
Tên gọi tại Việt Nam
Pha Chế & Hòa Hợp
Linalool (~75% of absolute) modulates GABA-A receptor activity and suppresses glutamate-driven neuronal excitation, producing dose-dependent anxiolytic effects via inhalation and transdermal absorption.
Ref: Tisserand & Young 2014, Ch.13 p.621-622; linalool mechanism class-extrapolated from peer linalool-dominant oils
Linalool combined with indole and jasmine-lactone narcotic-floral markers engages olfactory-limbic circuits, promoting sleep-onset through synergistic GABAergic and serotonergic modulation.
Ref: Tisserand & Young 2014, Ch.13 p.621-622 (narcotic-floral class characterization)
Indole and jasmine-lactone narcotic-floral markers stimulate olfactory-limbic pathways, promoting serotonergic uplift and emotional warmth characteristic of flower-absolute narcotic-floral class.
Ref: Tisserand & Young 2014, Ch.13 p.621-622; Joulain 1986 (volatile-constituent indole-class profile confirmed)
Linalool inhibits NF-kB-dependent pro-inflammatory cytokine release (IL-1beta, TNF-alpha); at use-level dilutions (0.5-1%) provides modest anti-inflammatory support to stressed or mature skin.
Ref: class-extrapolation from linalool-dominant oils (lavender, linaloe-wood)
Linalool disrupts Gram-positive bacterial cell membrane fluidity and inhibits spore germination; activity at typical cosmetic dilutions is supportive rather than standalone antimicrobial.
Ref: class-extrapolation from linalool-dominant oils (lavender, rosewood)
Linalool modulates L-type calcium channels and alpha1-adrenergic receptors, reducing smooth muscle contractility; relevant to tension-relief massage blends at 0.5-1% dilution.
Ref: class-extrapolation from linalool-dominant oils (lavender)
AI-summary
No RCT-grade clinical evidence exists for Lonicera periclymenum absolute. Safety data: Ford et al. 1988a reports clean sensitization patch test (3%/25 volunteers); phototoxicity only tested at 100% concentration (inconclusive for use-level dilutions); mutagenicity solvent-dependent (water+/DMSO-/B. subtilis-) consistent with solubility artifact per RIFM interpretation. Politano et al. 2008 (Int J Toxicol 27:183-188): linalool developmental toxicity negative, underpinning T&Y pregnancy clearance for linalool-dominant oils. Therapeutic ratings are class-extrapolated from linalool and narcotic-floral indole+jasmine-lactone constituent research. Tisserand & Young 2014 Ch.13 p.621-622 is the primary clinical reference. No Lonicera-specific controlled human therapeutic outcome studies identified.
NarrativeTâm trạng: Calming, Uplifting
Chakra
heart
Ngũ hành
hoa
| Phương pháp | Liều lượng | Ghi chú |
|---|---|---|
| Diffusion | 2-4 drops in 100 ml diffuser water | Evening/relaxation use. Narcotic-floral character is intense — use sparingly. Blend with sandalwood or bergamot to temper. 30-min sessions maximum. |
| Inhalation (personal inhaler) | 1-2 drops on inhaler wick or tissue | Acute anxiety or mood-support. Short sessions 5-10 min. Most efficient delivery via olfactory-limbic pathway. Max 3 inhalations per hour. |
| Topical massage | 0.5-1% in carrier oil (5-10 drops per 100 ml) | Use antioxidant-stabilized carrier (jojoba or fractionated coconut). Patch-test first; avoid oxidized stock. Not for pediatric use. |
| Skincare (facial) | 0.3-0.5% in facial serum or night cream | Night-use formulations preferred. Pair with jojoba or rosehip. Store blend in dark glass to prevent linalool oxidation sensitization. |
| Bath (aromatic) | 2-3 drops pre-dispersed in 1 tsp carrier oil | Pre-dilute in carrier before adding to bath — never add neat. Evening calming ritual. Avoid with broken or very sensitive skin. |
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