Hibawood essential oil (Thujopsis dolobrata var. hondai, Cupressaceae wood steam distillate from Japanese-endemic conifer commonly called Hiba / 翌檜 / asunaro) is a β-thujaplicin + β-dolabrin tropolone-class sesquiterpenoid wood oil with PREGNANCY + BREASTFEEDING CONTRAINDICATION (all routes) per Tisserand & Young Hazards line "May be reproductively toxic." B216 Ch.13 p.615 cites Morita et al 2004 chemistry: β-thujaplicin Major + β-dolabrin Major + α-thujaplicin Minor + γ-thujaplicin Minor + 4-acetyltropolone Minor (no quantitative %% — qualitative composition only). Reproductive toxicity rail driven by Ema et al 2004: oral β-thujaplicin reproductively toxic at 135 mg/kg (fetal malformations) + 45 mg/kg (decreased fetal weight) + NOAEL 15 mg/kg in rats; β-thujaplicin NOT estrogenic (Nishihara et al 2000). T&Y framework worst-case extrapolation: assuming whole oil is as reproductively toxic as β-thujaplicin pure → maximum oral dose 1,050 mg + maximum dermal use level 30% (T&Y Comments p.615 verbatim — high-cap dermal because tropolone potency is constituent-class extrapolation, not whole-oil patch evidence). Phototoxicity-NEGATIVE (Cupressaceae wood, no furocoumarins). Skin: undiluted moderately irritating to rabbits, NOT irritating to mice/pigs, non-irritating + non-sensitizing at 12% on 25 volunteers (Opdyke 1979a p.817). CYP2B1 induction in male rat hepatic microsomes (Hiroi 1995) — NOT at level suggestive of clinical drug interaction. Continues Mini-Batch 21a contrast trio (hemp latent-oxidation + hibawood pregnancy-contraindicated + hinoki-leaf clean). Tropolone-class singleton in Phase 3 mass-ingest — first oil with β-thujaplicin/β-dolabrin/4-acetyltropolone tropolone-aromatic ring chemistry.
Tổng Quan
- Danh pháp khoa học
- Thujopsis dolobrata (L. fil.) Siebold & Zucc. var. hondai Makino
- Họ thực vật
- Cupressaceae
- Bộ phận dùng
- Wood
- Phương pháp chiết xuất
- steam_distillation
- Màu sắc
- —
- Phân loại nốt hương
- Nốt Middle
- Hương thơm
- —
- Chemotype / Cultivar
- —
Các quốc gia sản xuất chính
Tình trạng tại Việt Nam
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Ancient Japanese heartwood, dry and quietly antiseptic, cedar-kin warmth, faint metallic-clean edge of tropolones, still and grounding
Lõi gỗ Nhật Bản cổ xưa, khô ráo và kháng khuẩn thầm lặng, hơi ấm họ tuyết tùng, thoáng cạnh kim loại-sạch từ tropolone, tĩnh lặng vững chãi
2–4 giờ
Tên gọi tại Việt Nam
Pha Chế & Hòa Hợp
β-Thujaplicin's tropolone 7-membered ring chelates essential metal ions (Fe²⁺, Cu²⁺, Zn²⁺) required by microbial metalloenzymes, disrupting cell membrane integrity and halting bacterial/fungal metabolic pathways.
Ref: Morita Y et al. (2004), Biological & Pharmaceutical Bulletin 27:899–902
β-Thujaplicin and isomer α-thujaplicin inhibit ergosterol-related biosynthesis and disrupt fungal cell walls via metal ion sequestration; in vitro activity confirmed against multiple fungal strains.
Ref: Morita Y et al. (2002, 2003), Biological & Pharmaceutical Bulletin — antimicrobial activity series
Tropolone compounds (β- and α-thujaplicin) exhibit cytotoxicity against tumor cell lines in vitro, likely via metal chelation disrupting cell-cycle metalloenzymes; no in vivo or clinical translation established.
Ref: Matsumura E et al. (2001), Bioscience, Biotechnology & Biochemistry 65:1647–1649; Morita Y et al. (2002, 2003)
β-Thujaplicin's metal-chelating tropolone ring suppresses biofilm formation in Gram-positive and Gram-negative bacteria, consistent with the legendary rot-resistance of Thujopsis dolobrata timber.
Ref: Morita Y et al. (2004), Biological & Pharmaceutical Bulletin 27:899–902; Tisserand & Young (2014), Ch. 13 p. 615
Woody sesquiterpene volatiles interact with limbic olfactory pathways; hibawood's sacred-timber cultural positioning mirrors Cupressaceae peers where controlled inhalation studies support parasympathetic calming.
Ref: class-extrapolation from hinoki-wood (Cupressaceae heartwood, same family and wood tissue)
Tropolone ring chelation reduces metal-catalysed oxidative stress and may inhibit pro-inflammatory metalloproteinases; effect size at aromatherapy-relevant concentrations has not been quantified.
Ref: class-extrapolation from Cupressaceae wood oils; Morita Y et al. (2004), tropolone bioactivity series
AI-summary
No RCT-grade clinical aromatherapy evidence exists for hibawood. The strongest data are in vitro: Matsumura et al. (2001) demonstrated cytotoxicity of hibawood tropolones against tumor cell lines; Morita et al. (2002–2004) confirmed broad antimicrobial and antifungal activity of β-thujaplicin via metal ion chelation. Key safety data: Ema et al. (2004) established oral reproductive toxicity in rats — fetal malformations at 135 mg/kg, decreased fetal weight at 45 mg/kg, NOAEL 15 mg/kg — basis for all-route pregnancy/breastfeeding contraindication. Imai et al. (2006) found no carcinogenicity in F344 rats. Nishihara et al. (2000) confirmed β-thujaplicin is NOT estrogenic. Opdyke (1979a) provided the sole human safety data: 12% patch test in 25 volunteers was neither irritating nor sensitizing; non-phototoxic; oral and dermal LD50 > 5 g/kg. Tisserand & Young (2014) derive max dermal 30% and max oral 1050 mg/day.
NarrativeTâm trạng: Grounding, Calming
Chakra
root
Ngũ hành
kim
| Phương pháp | Liều lượng | Ghi chú |
|---|---|---|
| Diffusion | 3–5 drops in 100 ml water (ultrasonic diffuser) | Grounding atmosphere with mild antimicrobial air benefit. Avoid in spaces occupied by pregnant women. Maximum 30–60 min continuous diffusion. |
| Topical massage | 1–2% in carrier oil (10–20 drops per 100 ml carrier) | Well within T&Y max dermal 30%. CONTRAINDICATED in pregnancy and breastfeeding. Patch test recommended for first use. Avoid mucous membranes. |
| Skincare (oily / acne-prone) | 0.5–1% in facial serum or carrier oil | Antimicrobial tropolone activity suits oily and acne-prone skin; pair with jojoba. Not recommended during pregnancy. Avoid eye area. |
| Direct inhalation | 1–2 drops on unscented tissue | Brief inhalation for grounding or focus. Do not apply tissue to nostrils directly. Safe for non-pregnant adults only. |
| Bath | 4–6 drops dispersed in 1 tsp emulsifier before adding to water | CONTRAINDICATED in pregnancy and breastfeeding. Use full-fat milk or shower gel as emulsifier. Water temperature ≤ 38 °C to limit absorption rate. |
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