Hemp essential oil (Cannabis sativa L., Cannabaceae flowering-tops steam distillate from low-THC industrial cultivars) is a β-myrcene + β-caryophyllene + α-pinene + (E)-β-ocimene + terpinolene monoterpene-hydrocarbon-dominant oil with a latent-oxidation hazard only Tisserand & Young profile — no toxicity in fresh oil but skin sensitization if oxidized due to combined (+)-limonene, α-pinene and δ-3-carene autoxidation potential. B216 Ch.13 p.613–614 cites two commercial chemotypes: French (Meier & Mediavilla 1998 + Sonnay 2011 — β-myrcene 31.1% + β-caryophyllene 13.7% + (E)-β-ocimene 10.2% + terpinolene 8.9% + α-pinene 7.6%) and Swiss (β-myrcene 21.2–31.1% + β-caryophyllene 14.3–19.4% + α-pinene 14.3–19.4% — different chemotype with higher α-pinene). Framework caps with α-pinene+δ-3-carene autoxidation caveat: adult dermal 5.0% + sensitive 3.0% + pregnancy 5.0% + pediatric cascade + max_oral 700 mg/day. Storage imperative: dark + airtight + refrigerator + antioxidant (T&Y verbatim p.614). Canadian Industrial Hemp Regulations cap: 10 µg/g THC in cosmetics (Health Canada 2011). Continues Mini-Batch 21a clean-or-latent trio (hemp + hibawood + hinoki-leaf — but hibawood has pregnancy contraindication, hemp + hinoki-leaf are clean-or-latent only). Forms β-myrcene-rich peer with grindelia EO736 (20b) at the highest end of the class — confirmed forward reference fulfilled.
Tổng Quan
- Danh pháp khoa học
- Cannabis sativa L.
- Họ thực vật
- Cannabaceae
- Bộ phận dùng
- Flowering tops
- Phương pháp chiết xuất
- steam_distillation
- Màu sắc
- —
- Phân loại nốt hương
- Nốt Top
- Hương thơm
- —
- Chemotype / Cultivar
- —
Các quốc gia sản xuất chính
Tình trạng tại Việt Nam
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Pungent forest-floor musk, sun-warmed resinous flowering tops, deep vegetal earthiness with a musky pulse, faintly tropical-fruity undertone like sun-ripened mango at dusk, quiet woody spice from the undergrowth
Đất rừng nồng nàn hăng mùi xạ, hoa khô nhựa ấm dưới nắng hè, lòng đất thực vật sâu thẳm mang nhịp thở mộc mạc, thoảng hương nhiệt đới như xoài chín chiều tà, gia vị gỗ trầm lặng từ lòng rừng
2–4 giờ
Tên gọi tại Việt Nam
Pha Chế & Hòa Hợp
Monoterpene hydrocarbons (β-myrcene 21–31%, α-pinene, (+)-limonene) and sesquiterpene constituents synergistically disrupt bacterial cell membranes and inhibit microbial respiratory enzymes across multiple industrial hemp EO varieties.
Ref: Nissen L et al. (2010) Fitoterapia 81:413–419
Hemp EO terpene fractions demonstrated direct inhibition of food-spoilage and bread-mould fungal species in standardized in-vitro microbiological assays across multiple industrial hemp varieties.
Ref: Nissen L et al. (2010) Fitoterapia 81:413–419
β-Caryophyllene, a sesquiterpene constituent of hemp flowering-tops EO, binds CB2 receptors as a partial agonist and down-regulates NF-κB-mediated pro-inflammatory cytokine cascades.
Ref: Gertsch J et al. (2008) PNAS 105:9099–9104 — direct β-caryophyllene constituent data; sesquiterpene fraction confirmed present in hemp EO chemotype
CB2 partial agonism by β-caryophyllene modulates peripheral nociceptor signalling independently of central opioid pathways; most relevant via topical application over inflamed or sore tissue.
Ref: class-extrapolation from β-caryophyllene CB2 agonism; Gertsch J et al. (2008) PNAS 105:9099–9104
β-Myrcene-dominant terpene profile (21–31%) is associated with CNS sedative and muscle-relaxant activity via GABA-A potentiation in rodent models; diffusion is the most applicable route.
Ref: Tisserand R, Young R (2014) Essential Oil Safety 2nd ed., Ch.13 p.613–614 — β-myrcene class sedative properties
AI-summary
No RCT-grade human clinical evidence for whole hemp essential oil as a therapeutic agent. The strongest controlled data is Nissen et al. (2010, Fitoterapia 81:413–419) — standardized in-vitro antimicrobial assays across multiple industrial hemp EO varieties documenting inhibition of bacterial and mould species. Constituent-level mechanistic evidence: Gertsch et al. (2008, PNAS 105:9099–9104) demonstrated β-caryophyllene as a CB2 receptor partial agonist in receptor-binding and cell-culture assays; this sesquiterpene is present in hemp EO's minor fraction. Composition studies (Meier & Mediavilla 1998; Sonnay 2011; Mediavilla & Steinmann 1997) provide reliable chemistry anchoring without therapeutic endpoints. β-Myrcene toxicology (Delgado 1993a/b; NTP 2010a) is safety-oriented only. Traditional aromatherapy use; no RCT-grade human clinical evidence located.
NarrativeTâm trạng: Grounding, Calming
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| Phương pháp | Liều lượng | Ghi chú |
|---|---|---|
| Diffusion | 4–6 drops per 100 ml water in ultrasonic diffuser | Sessions 20–30 min; ventilate room between uses. Use only fresh oil with antioxidant added per IFRA 2009; refrigerated storage mandatory. |
| Topical massage | 1–2% in carrier oil (2–4 drops per 10 ml) | Max 5% T&Y framework. Use oxidation-stable carrier (jojoba, fractionated coconut). Only fresh oil — oxidised peroxides are sensitisers (Sköld 2008; IFRA 2009). |
| Skincare blend | 0.5–1% in facial formulation | Add 0.1% BHT or α-tocopherol per IFRA 2009. THC ≤10 µg/g in finished product required for cosmetic compliance (Health Canada 2011). |
| Direct inhalation | 1–2 drops on tissue or inhaler wick | Brief 2–3 inhalation sessions for acute relaxation. THC is non-volatile; steam-distilled hemp EO carries no psychoactive cannabinoids. |
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