Guaiacwood oil (Bulnesia sarmientoi, Zygophyllaceae wood steam-distillate) is a sesquiterpene-alcohol-dominant wood oil with one of the cleanest Tisserand & Young profiles in B216 Ch.13 — "Hazards: None known. Contraindications: None known." + 200-patient dermatology patch-test no-sensitization data (Rudzki et al 1976). Chemistry (Prudent et al 1991): bulnesol 40.5% + guaiol 26.8% dominant + 10-epi-γ-eudesmol 2.2% + guaiol isomer 1.4% + elemol 1.2% — 67.3% combined top-2 sesquiterpene alcohols. Framework caps apply: adult dermal 5.0% + sensitive 3.0% + pregnancy all trimesters 5.0% + pediatric cascade + max_oral 700 mg/day. Non-phototoxic; non-irritant + non-sensitizing at 8% on 25 volunteers + 0/200 dermatology patch-test sensitization (Rudzki 1976); LD50 oral rats > 5 g/kg + dermal rabbits > 5 g/kg; 90-day feeding NOAEL 31.8 mg/kg (Bär & Griepentrog 1967). CITES Appendix II listed (CRITICAL commercial compliance rail) — Bulnesia sarmientoi wood + extracts restricted from bulk international trade; "finished products packaged and ready for retail sale" exempt. Zygophyllaceae-singleton-in-B216-Ch13 + commercial "budget sandalwood substitute" in sesquiterpene-alcohol-wood class with [[sandalwood-east-indian]] + [[amyris]] + [[patchouli]] + [[vetiver]]. Center of Mini-Batch 20b clean-profile trio.
Tổng Quan
- Danh pháp khoa học
- Bulnesia sarmientoi Lorentz ex Griseb.
- Họ thực vật
- Zygophyllaceae
- Bộ phận dùng
- Wood
- Phương pháp chiết xuất
- steam_distillation
- Màu sắc
- —
- Phân loại nốt hương
- Nốt Base
- Hương thơm
- —
- Chemotype / Cultivar
- —
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Dry warm ancient timber, faintly smoky wood from deep within, soft rosy-balsamic whisper, powdery earthen stillness, quietly grounding like old-growth heartwood
Gỗ cổ thụ khô ấm trầm lặng, thoảng khói gỗ từ tầng sâu, thì thầm balsamic hồng ngọt, tịch lặng bột đất dịu dàng, vững chãi như lõi cây thụ đại
2–4 giờ
Tên gọi tại Việt Nam
Pha Chế & Hòa Hợp
Bulnesol (40.5%), a high-molecular-weight sesquiterpene alcohol, contributes a persistent woody-balsamic aromatic profile traditionally associated with CNS grounding and calming effects in inhalation aromatherapy.
Ref: Traditional aromatherapy use; class-extrapolation from vetiver and sandalwood sesquiterpene alcohol class (Tisserand & Young 2014, Ch.13)
Guaiol (26.8%), a guaiane-skeleton sesquiterpene alcohol, belongs to a constituent class associated with COX-pathway modulation and topical anti-inflammatory activity in related sesquiterpene-alcohol-rich wood oils.
Ref: class-extrapolation from guaiol-bearing wood oils; Prudent et al 1991 (composition); Tisserand & Young 2014, Ch.13
Combined sesquiterpene alcohol load (bulnesol + guaiol ~67%) supports lipid-film formation and skin barrier integrity, consistent with long-standing cosmetic and perfumery application at framework concentrations.
Ref: Opdyke DLJ (1974) — non-sensitizing, non-irritating at 8% HRIPT 25 volunteers; Rudzki et al (1976) — 0/200 sensitization at 2%
Two independent patch-test datasets (Opdyke 1974: HRIPT 8%/25 volunteers; Rudzki 1976: 0/200 consecutive dermatitis patients at 2%) represent one of the strongest combined no-sensitization safety profiles in B216 Ch.13.
Ref: Opdyke DLJ (1974), Food & Cosmetics Toxicology 12:905; Rudzki E et al (1976), Contact Dermatitis 2:196–200
Sesquiterpene alcohols in the bulnesane and guaiane skeleton classes exhibit mild radical-scavenging capacity in in-vitro assays of structurally related wood oils; no guaiacwood-specific antioxidant data identified.
Ref: class-extrapolation from sesquiterpene alcohol-dominant wood oils (Tisserand & Young 2014, Ch.13)
High-boiling sesquiterpene alcohols (bulnesol MW ~222 Da) retard volatilization of lighter-fraction compounds in blends, extending aromatic persistence — classical role as natural rosewood substitute in perfumery.
Ref: Traditional perfumery use; Tisserand & Young 2014, Ch.13
AI-summary
No RCT-grade clinical efficacy trials for guaiacwood essential oil were located in the available literature. Safety data constitutes the strongest body of evidence: Opdyke (1974) conducted a Human Repeat Insult Patch Test (HRIPT) at 8% on 25 volunteers confirming a non-sensitizing and non-irritating profile, with oral and dermal LD50 > 5 g/kg in rodents and non-phototoxic status. Rudzki et al (1976) patch-tested 200 consecutive dermatitis patients at 2% with zero sensitization reactions — one of the cleanest sensitization datasets in Tisserand & Young Ch.13. A 90-day rat feeding study (Bär & Griepentrog 1967; Oser et al 1965) established NOAEL at 30.7–36.0 mg/kg/day. All therapeutic action claims rely on traditional aromatherapy practice and class-extrapolation from sesquiterpene alcohol peers. T&Y 2014 explicitly lists both hazards and contraindications as 'None known'.
NarrativeTâm trạng: Grounding, Calming
Chakra
root
Ngũ hành
kim
| Phương pháp | Liều lượng | Ghi chú |
|---|---|---|
| Diffusion / Inhalation | 3-5 drops in 100 ml diffuser water | Blends well with sandalwood, vetiver, rose, jasmine. Persistent base-note; session 30-60 min. Grounding, meditation, stress-relief. T&Y: contraindications None known. |
| Topical massage | 1-2% in carrier oil (5% framework max, T&Y Ch.13) | Non-irritating at 8% HRIPT (Opdyke 1974); 0/200 sensitization at 2% (Rudzki 1976). Conservative 1-2% for routine use; 5% acceptable for short-duration targeted work. |
| Skincare / cosmetic formulation | 0.5-1% in face cream; up to 2% in body lotion | Non-phototoxic (Opdyke 1974) — safe for leave-on and daytime use. Suits mature/dry skin formularies as woody-balsamic fixative and skin-conditioning agent. |
| Aromatic bath | 4-6 drops dispersed in bath emulsifier first | Disperse in carrier oil, full-fat milk, or liquid soap before water entry. Low sensitization profile (Rudzki 1976) suits general use. Water ≤ 38°C; session 15-20 min. |
| Personal inhaler | 5-8 drops on inhaler wick | Slow-release woody-balsamic profile suited to on-demand grounding. Non-phototoxic — safe for daytime portable use. Combine with citrus or floral top notes for balance. |
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