Grindelia oil (Grindelia oregana, Asteraceae tribe Astereae aerial-parts steam-distillate) is a β-myrcene + α-pinene dominant monoterpene-hydrocarbon oil with a latent-hazard-only Tisserand & Young profile — no known toxicity in fresh oil, but skin sensitization if oxidized and an unusual tendency to polymerize. B216 Ch.13 p.610 chemistry (Apostolova 1999 private comm): β-myrcene 14.0–26.0% + α-pinene 17.0–24.0% + citronellol 1.0–5.0% + longifolene 1.0–2.5% + nonadecane 0.4–1.0%. Framework caps apply with α-pinene-autoxidation + polymerization double caveat: adult dermal 5.0% + sensitive 3.0% + pregnancy all trimesters 5.0% + pediatric cascade + max_oral 700 mg/day. Storage imperative: dark + airtight + refrigerator + antioxidant at production (short shelf life due to polymerization). Limited availability, produced in Bulgaria per T&Y Comments. Opens Mini-Batch 20b clean-or-latent trio (grindelia + guaiacwood + gurjun — 3/3 "Hazards: None known" or oxidation-caveat-only) and forms first consecutive tribe-Astereae pair across batch boundary with goldenrod EO735 (20a).
Tổng Quan
- Danh pháp khoa học
- Grindelia oregana A. Grey
- Họ thực vật
- Asteraceae
- Bộ phận dùng
- Aerial parts
- Phương pháp chiết xuất
- steam_distillation
- Màu sắc
- —
- Phân loại nốt hương
- Nốt Top
- Hương thơm
- —
- Chemotype / Cultivar
- —
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Fresh-cut wild herbs on a wind-swept hillside, resinous piney crispness with a biting edge, softly balsamic green depth, warm rosy trace from scattered meadow blooms, quietly clean and invigorating
Thảo mộc dại vừa hái trên sườn đồi gió thổi, nhựa thông the mát và sắc sảo, chiều sâu xanh mướt ngọt nhựa, thoảng ấm hương hoa đồng xa xôi, trong lành sảng khoái không ồn ào
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Pha Chế & Hòa Hợp
β-Myrcene, the dominant constituent of Grindelia EO, modulates peripheral pain signaling via opioid-like pathways in rodent models; constituent-class evidence supports mild analgesic activity at therapeutic dilutions.
Ref: class-extrapolation from β-Myrcene constituent research; Tisserand & Young 2014, Ch.13
β-Myrcene inhibits prostaglandin-mediated inflammatory cascades in vitro and in rodent models; constituent-class effect shared across β-myrcene-dominant EOs such as hemp and bay.
Ref: class-extrapolation from β-Myrcene constituent research; Tisserand & Young 2014, Ch.13
β-Myrcene demonstrates sedative and anxiolytic activity in rodent models, tentatively attributed to GABA-A receptor potentiation and central nervous system depression.
Ref: class-extrapolation from β-Myrcene constituent research; Tisserand & Young 2014, Ch.13
β-Myrcene and α-pinene class exhibit smooth-muscle relaxant activity; constituent-class extrapolation supports mild antispasmodic use in massage blends targeting musculoskeletal tension.
Ref: class-extrapolation from β-Myrcene and α-Pinene constituent class; Tisserand & Young 2014, Ch.13
Grindeliae herba USP (1882–1926) attributes bronchial antispasmodic and mucolytic action to the whole plant; however, responsible saponins, resins, and polysaccharides are non-volatile and DO NOT distill into steam-distilled EO — this action is NOT attributable to the EO.
Ref: US Pharmacopeia 1882–1926 (Grindeliae herba fluid extract — WHOLE PLANT, not EO); Tisserand & Young 2014, Ch.13
Monoterpene hydrocarbons including β-myrcene and α-pinene demonstrate mild membrane-disrupting antimicrobial activity in vitro; weaker than terpenol-class oils and evidenced only at supra-therapeutic concentrations.
Ref: class-extrapolation from monoterpene hydrocarbon EO class; Tisserand & Young 2014, Ch.13
AI-summary
No RCT-grade or controlled clinical evidence has been located specifically for Grindelia EO. The cited literature comprises: (1) β-Myrcene reproductive/developmental toxicity studies in rats (Delgado 1993a/b, Paumgartten 1998) — hazard characterisation only; (2) NTP 2010a β-myrcene hepatocarcinogenicity in male mice only, not extrapolable to human aromatherapy use per T&Y 2014; (3) α-Pinene autoxidation and contact sensitization class evidence (Karlberg 1992/1994, Sköld 2008) — safety only; (4) Grindeliae herba USP tradition (whole-plant fluid extract; non-volatile active constituents absent from steam-distilled EO). All therapeutic action ratings are class-extrapolated from β-myrcene and α-pinene constituent research. Traditional aromatherapy use; no RCT-grade clinical evidence located for the EO itself.
NarrativeTâm trạng: Uplifting, Grounding
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| Phương pháp | Liều lượng | Ghi chú |
|---|---|---|
| Diffusion | 3–5 drops per 100 ml water in ultrasonic diffuser | Preferred route; limits oxidation exposure. Run 30-minute intervals only; avoid continuous use due to β-myrcene sedative effect. Blend with citrus or conifer EOs to broaden the profile. |
| Topical massage | 0.5–1% in carrier oil (T&Y framework max 5%; 1% recommended given oxidation and polymerization risk) | Use only fresh, antioxidant-stabilised oil. Avoid on sensitised or broken skin; α-pinene oxidation products risk contact sensitisation. Patch-test recommended. Do not use on face of children under 2. |
| Steam inhalation | 2–3 drops in bowl of hot water, inhale 5–10 minutes | EO lacks the non-volatile saponins of Grindeliae herba; respiratory effect is terpene-vapour only. Not recommended for asthma or COPD without professional guidance. |
| Personal inhaler / tissue | 2–3 drops on inhaler wick or tissue | Suitable for tension and stress relief via β-myrcene anxiolytic class effect. Use intermittently; avoid prolonged direct nasal contact with undiluted oil. |
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