- Callitris intratropica R.T. Baker & H.B. Sm. (Cupressaceae) — steam distillate from wood; synonym "Northern cypress pine". Sometimes produced by solvent extraction followed by steam distillation or rectification (Burfield 2000). NOT the Mediterranean Cypress Cupressus sempervirens — different genus + family context.
- Hazards: Drug interaction; may be fetotoxic (based on β-eudesmol content). Contraindications (all routes): Pregnancy and lactation. Cautions (oral): Low blood pressure, drugs metabolized by CYP2D6 (Appendix B).
- Dermal cap — no specific T&Y quantitative limit; framework 2–3% conservative given cautionary profile. Non-phototoxic. Non-mutagenic (Ames, McGilvray 1999). Skin: mildly irritating at 100% + 75% rabbits; sensitization 80% (16/20 guinea pigs) at 100% but 0% at ≤75%.
- Acute toxicity — non-toxic: Oral LD50 rats > 2 g/kg; dermal LD50 rats > 2 g/kg (McGilvray 1999 private communication). High radical scavenging activity both ABTS + DPPH (Zhao et al 2008).
- Key rails: β-Eudesmol antiangiogenic (Tsuneki et al 2005) + probable link between antiangiogenic effects + reproductive toxicity (Chaiworapongsa 2010; Zhou 2013) → T&Y contraindicates pregnancy + lactation. Chamazulene inhibits CYP2D6 (Table 4.11B) → theoretical interaction with drugs metabolized by this enzyme. Guaiol + β-eudesmol hypotensive (Arora et al 1967).
Tổng Quan
- Danh pháp khoa học
- Callitris intratropica R.T. Baker & H.B. Sm.
- Họ thực vật
- Cupressaceae
- Bộ phận dùng
- Wood
- Phương pháp chiết xuất
- steam_distillation
- Màu sắc
- Distinctive blue tint from guaiazulene + chamazulene content
- Phân loại nốt hương
- Nốt Base
- Hương thơm
- —
- Chemotype / Cultivar
- —
Tình trạng tại Việt Nam
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Phân loại nốt
Base
Cường độ
3/5
Độ bền trên da
2–4 giờ
Họ hương
Woody-balsamic-sweet with chamomile-azulene undertone + subtle dried-fruit facet
Hương đầu (Opening)(0–15 phút)
Deep warm heartwood tinged with cool azure blue, ancient timber breathing slowly, softly camphoraceous shadow, quiet amber resin settling in still air, immovable and grounding
Hương giữa (Heart)(15–60 phút)
Lõi gỗ ấm sâu pha sắc xanh lam dịu lạnh, gỗ cổ thở chậm như ngủ đông, bóng camphor mơ hồ dịu nhẹ, nhựa hổ phách yên tĩnh lắng đọng, vững chãi không lay chuyển
Hương nền (Drydown)(1–4 giờ)
2–4 giờ
Cường độ hương
3/5
Da khô
2/5
Da dầu/mụn
3/5
Da lão hóa
4/5
Da thường
3/5
Da nhạy cảm
2/5
Da hỗn hợp
3/5
Nhập khẩuImported
Tên gọi tại Việt Nam
Tinh dầu Cypress Xanh (Bách xanh phương Bắc)
Pha Chế & Hòa Hợp
hypotensive
Guaiol and β-eudesmol lower blood pressure via smooth muscle relaxation, demonstrated in animal model studies.
Ref: Arora et al (1967)
antiangiogenic
β-Eudesmol inhibits new blood vessel formation (angiogenesis) in vitro; this mechanism is also the basis for the hard pregnancy contraindication due to fetotoxic risk.
Ref: Tsuneki et al (2005); Chaiworapongsa (2010); Zhou (2013)
anticarcinogenic (in vitro)
γ-Eudesmol demonstrated anticarcinogenic activity in cell-culture assays; no in vivo or clinical corroboration available from cited sources.
Ref: Hsieh (2001)
antioxidant
Crude oil quenched ABTS and DPPH free radicals in vitro, attributed to sesquiterpene alcohol constituents including guaiol and eudesmol congeners.
Ref: Zhao et al (2008)
grounding / sedative (aromatic)
Sesquiterpene alcohol-dominant Cupressaceae wood oils traditionally produce calming, grounding psycho-aromatic effects via olfactory pathway modulation.
Ref: class-extrapolation from sandalwood-australian (Tisserand & Young 2014, Ch.13)
anti-inflammatory (mild)
Guaiol is a shared sesquiterpene alcohol with guaiacwood; guaiol-class oils have shown COX-pathway anti-inflammatory activity in preclinical models of related species.
Ref: class-extrapolation from guaiacwood (guaiol shared constituent; Tisserand & Young 2014, Ch.13)
AI-summary
No RCT-grade human clinical trials have been located for Callitris intratropica. Available evidence is entirely preclinical: Arora et al (1967) demonstrated guaiol + β-eudesmol hypotensive activity in animal models; Tsuneki et al (2005) confirmed β-eudesmol antiangiogenic activity in vitro, corroborated by Chaiworapongsa (2010) and Zhou (2013) linking antiangiogenic effects to reproductive toxicity — the mechanistic basis for the hard pregnancy contraindication. Hsieh (2001) reported γ-eudesmol anticarcinogenic effects in cell culture only. Zhao et al (2008) showed ABTS + DPPH radical-scavenging activity in vitro. McGilvray (1999) reported clean acute toxicity (LD50), Ames test, and skin/sensitization profiles, underpinning the 3% max dermal limit per Tisserand & Young (2014).
NarrativeTâm trạng: Grounding, Calming
anxietyrestlessnessdisconnectionprotectionstillnessintrospection
Chakra
root
Ngũ hành
kim
| Phương pháp | Liều lượng | Ghi chú |
|---|---|---|
| Diffusion | 3-5 drops in 100ml water | Khuếch tán 30–60 phút tạo không khí trầm tĩnh, gần gũi thiên nhiên. Không dùng liên tục quá 1 giờ. Tránh dùng trong phòng có phụ nữ mang thai. |
| Topical massage | 1–3% in carrier oil (max 3.0% adult) | Pha với jojoba hoặc dầu hạnh nhân ngọt. Tuyệt đối không dùng cho phụ nữ mang thai (contraindicated_pregnancy = TRUE). Patch test before first use. |
| Inhalation (direct) | 1-2 drops on tissue or palm | Hít 3–5 nhịp chậm để tạo cảm giác thư giãn và cân bằng nhanh. Tránh tiếp xúc trực tiếp lâu với mũi. |
| Skincare blend | 1–2% in facial carrier | Dành cho da trưởng thành và da thường. Giữ dưới 2% khi thoa mặt do trần 3% dermal. Kết hợp rosehip hoặc jojoba. Không dùng khi mang thai. |
Dầu nền phù hợp
JojobaNon-comedogenic wax ester; highly stable with long shelf life; neutral profile allows the wood-resinous character to express; suitable for both facial and body application.
Sweet AlmondLight oleic-rich carrier ideal for massage blends; neutral scent does not compete with blue cypress's woody aromatic character.
RosehipHigh linoleic acid and natural antioxidant carotenoids complement the oil's in-vitro antioxidant activity (Zhao et al 2008); well-suited to mature skin applications.
Fractionated CoconutLightweight, odourless, and indefinitely stable; extends shelf life of the diluted blend and makes an all-purpose base for massage.
Kết hợp tốt với
WoodyResinousEarthyCamphoraceousFloral
Blend kinh điển
—
—
—
—
[Tisserand & Young] Ch.13 p.556–557 (Cypress, blue)
[Doimo] chemistry profile
[McGilvray] LD50, Ames, skin + sensitization testing
[Arora et al] guaiol + β-eudesmol hypotensive
[Tsuneki et al] β-eudesmol antiangiogenic
[Chaiworapongsa] antiangiogenic + pregnancy link
[Zhou] antiangiogenic + reproductive toxicity
[Hsieh] γ-eudesmol anticarcinogenic
[Zhao et al] ABTS + DPPH radical scavenging
[Burfield] extraction methods (solvent + steam + rectification)
An Toàn
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Giới hạn IFRA
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Thai kỳ & Cho con bú
Tam cá nguyệt 1Unknown
Tam cá nguyệt 2Unknown
Tam cá nguyệt 3Unknown
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