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Tinh dầu buchu chemotype diosphenol

Buchu Diosphenol

Agathosma betulina Bergius

TopThảo mộc

Sắc bén cassis-bạc hà cắt lạnh, lá lý đen ngậm sương sớm, xanh hoang dại thoảng mùi lưu huỳnh, ánh citrus vút lên từ bóng thảo mộc, mãnh liệt và đánh thức giác quan

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Tóm Tắt Khoa Học

Từ Thư Viện Kinh Điển
  1. Agathosma betulina Bergius (Rutaceae) — lá (leaves), steam-distilled essential oil. CHEMOTYPE-SPLIT CRITICAL: Đây là diosphenol CT (9.1% total pulegone, safer); KHÔNG CONFUSE với Agathosma crenulata pulegone CT ở [[buchu-pulegone]] (81.9% total pulegone, abortifacient + severe hepatotoxic). Hai species khác nhau + hai safety profile khác nhau hoàn toàn.
  2. Primary hazard = hepatotoxicity (low risk); skin sensitization if oxidized. Contraindicated pregnancy + breastfeeding (all routes) do pulegone content + uncertain reproductive toxicity.
  3. Chemistry: Isomenthone 4.6–29.1% + (+)-limonene 11.6–28.2% + diosphenol 12.0–26.3% (signature namesake) + menthone 2.5–25.0% + ψ-diosphenol 10.3–23.3% + 8-mercapto-p-menthan-3-one (cis+trans) 0.7–6.6% + α-pulegone 0.4–4.6% + (1S)-(–)-β-pulegone 0.6–4.5%. Total pulegone content ~9.1% (α + β combined).
  4. Maximum adult daily oral dose: 384 mg. Maximum dermal use level: 11%. Caps derived from 9.1% total pulegone × 0.5 mg/kg/day oral (CEFS TDI) ÷ 70 kg + 1% pulegone dermal limit ÷ 9.1% = 11%. Substantially higher caps than pulegone CT (384 mg oral vs no-oral-use; 11% dermal vs 1.4% dermal).
  5. Limonene oxidation caveat: Because of (+)-limonene 11.6–28.2%, storage must be dark + airtight + refrigerated + antioxidant (BHT 0.1%). Oxidized material can cause skin sensitization (IFRA limonene oxidation guidance). Avoid old oils. Adulteration với monoterpene sulfides documented (Burfield 2003).
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Thận trọngNốt TopHerbal-minty-cassis-black-currant-medicinal

Buchu Diosphenol

Tinh dầu buchu chemotype diosphenol

Agathosma betulina Bergius

Tinh dầu buchu chemotype diosphenol — Herbal-minty-cassis-black-currant-medicinal

⚠️Tinh dầu này cần thận trọng khi sử dụng. Đọc kỹ hướng dẫn an toàn.

Tổng Quan

Danh pháp khoa học
Agathosma betulina Bergius
Họ thực vật
Rutaceae
Bộ phận dùng
Leaves
Phương pháp chiết xuất
steam_distillation
Màu sắc
Phân loại nốt hương
Nốt Top
Hương thơm
Chemotype / Cultivar

Tình trạng tại Việt Nam

Xem chi tiết

Phân loại nốt
Top
Cường độ
4/5
Độ bền trên da
2–4 giờ
Họ hương
Herbal-minty-cassis-black-currant-medicinal
Hương đầu (Opening)(0–15 phút)

Biting cassis-mint sharpness, cool blackcurrant leaf soaked in morning dew, bracingly sulfurous and green-wild, citrus spark lifting through dense herbal shadow, fierce and invigorating

Hương giữa (Heart)(15–60 phút)

Sắc bén cassis-bạc hà cắt lạnh, lá lý đen ngậm sương sớm, xanh hoang dại thoảng mùi lưu huỳnh, ánh citrus vút lên từ bóng thảo mộc, mãnh liệt và đánh thức giác quan

Hương nền (Drydown)(1–4 giờ)

2–4 giờ

Cường độ hương
4/5
Da khô
2/5

Da dầu/mụn
4/5

Da lão hóa
2/5

Da thường
3/5

Da nhạy cảm
2/5

Da hỗn hợp
3/5

Nhập khẩuImported

Tên gọi tại Việt Nam

Tinh dầu buchu chemotype diosphenol

Pha Chế & Hòa Hợp

urinary antiseptic

Diosphenol constituent exerts bacteriostatic and antiseptic activity in the urogenital tract, supporting traditional use for urinary tract health.

Ref: Tisserand & Young 2014, Ch.13 p.482–483; Bradley 1992, British Herbal Compendium

antimicrobial (broad-spectrum)

Monoterpene ketone constituents (diosphenol, menthone, isomenthone) and limonene disrupt microbial membrane integrity, providing moderate broad-spectrum antimicrobial activity.

Ref: Collins et al 1996; Tisserand & Young 2014, Ch.13 p.482–483

anti-inflammatory

Limonene and menthone-class monoterpenes modulate pro-inflammatory mediator production; class extrapolation from peppermint and related menthone-dominant oils.

Ref: class-extrapolation from peppermint (menthone class); Collins et al 1996 (constituent identification)

diuretic (mild)

Traditional diuretic action attributed to diosphenol and monoterpene sulfide constituents; primary evidence base is whole-plant herbal preparations, not the isolated EO.

Ref: Bradley 1992, British Herbal Compendium (herbal preparation; EO-specific diuretic data not located)

deodorant / body-odour control

8-Mercapto-p-menthan-3-one sulfide marker provides intense blackcurrant top note; at low dilutions supports functional deodorising in personal care formulations.

Ref: Burfield 2003 (monoterpene sulfide authentic marker); Tisserand & Young 2014, Ch.13 p.482–483

analgesic / counterirritant

Menthone and isomenthone constituents activate TRPM8 cold-receptor channels at the skin surface, producing mild counterirritant analgesia; class extrapolation from menthone-containing mint EOs.

Ref: class-extrapolation from peppermint / cornmint (menthone class, TRPM8 mechanism); Collins et al 1996

AI-summary

Traditional aromatherapy use; no RCT-grade clinical evidence located for the EO itself. The strongest documented support derives from the British Herbal Compendium (Bradley 1992), which records Agathosma betulina leaves as a traditional urinary antiseptic and diuretic in South African and European herbalism. Tisserand & Young (2014) Ch.13 pp.482–483 characterises the diosphenol chemotype as the safety-preferred CT over the pulegone CT, with a maximum adult dermal limit of 11.0%. Chemistry profiling by Collins et al (1996) confirms diosphenol and monoterpene ketone dominance. No controlled human trials or systematic reviews specific to this EO chemotype were identified in the available citation pool.

Narrative

Tâm trạng: Stimulating, Uplifting

alertnessinvigorationwildnessclaritymental sharpnessrefreshment

Chakra

throat

Ngũ hành

kim

Phương phápLiều lượngGhi chú
Topical massage1–2% in carrier oil (~3–6 drops per 10 ml)Apply over lower back or abdomen for urinary/kidney support. Max adult dermal 11% per T&Y; conservative 1–2% blend recommended. Contraindicated in pregnancy (Bradley 1992; T&Y 2014).
Diffusion3–4 drops in 100 ml water (ultrasonic diffuser)20–30 min sessions for antimicrobial air deodorising. Sulfide note is intense neat; blend with lemon or bergamot to moderate the blackcurrant-cat top note.
Inhalation (steam)1–2 drops in bowl of hot water; inhale 5–10 minSupports respiratory mucosa. Cover head with towel; keep eyes closed. Avoid during pregnancy.
Skincare blend0.5–1% in lightweight carrier (jojoba, squalane)Use at conservative dilution for oily or blemish-prone skin. Not recommended for sensitive or dry skin. Avoid UV exposure 12 h post-application if citrus co-ingredients present (IFRA 2009).
Aromatic bath4–6 drops pre-dispersed in 1 tsp carrier or full-fat milkPre-dilute before adding to bath — never add neat EO to water. Contraindicated in pregnancy. Limit to 15–20 min soak.

Dầu nền phù hợp

JojobaStable wax ester, oxidation-resistant — complements limonene shelf-life sensitivity (IFRA 2009); non-comedogenic, ideal for oily/blemish-prone skin where buchu's antiseptic action is most relevant.
Sweet AlmondLight emollient with neutral scent that does not compete with buchu's distinctive sulfide-blackcurrant note; good spreading for lower-back massage applications.
Fractionated CoconutHighly stable, odourless, pairs with buchu's diosphenol antimicrobial profile without adding competing aromas; long shelf life supports formulation stability.
SqualaneUltra-lightweight, non-greasy and oxidation-resistant; suited to conservative (0.5–1%) facial or body skincare formulations targeting oily or congested skin types.

Kết hợp tốt với

CitrusGreenCamphoraceousSpicy

Blend kinh điển

[Tisserand & Young] Ch.13 p.482–483 (Buchu diosphenol CT) + Ch.14 β-Pulegone + (+)-Limonene profiles
[Collins, N. F. et al] chemistry profile (A. betulina + A. crenulata)
[Anon] CEFS pulegone TDI 0.1 mg/kg (pulegone + menthofuran combined)
[IFRA] limonene-rich oil antioxidant + shelf-life guidance
[Bradley, P. R.] British Herbal Compendium pregnancy contraindication for buchu leaves
[Burfield, T.] monoterpene sulfide adulteration documentation

An Toàn

Giới hạn da tối đa

Xem chi tiết

Giới hạn IFRA

Xem chi tiết

Thai kỳ & Cho con bú

Tam cá nguyệt 1Unknown
Tam cá nguyệt 2Unknown
Tam cá nguyệt 3Unknown

Giới hạn độ tuổi

Xem chi tiết

Bảo quản

Bảo quản nơi tối, mát

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Hồ Sơ Hoá Học Chi Tiết
§3 Chemical Profile — chemotype, constituent ranges, adulteration

Essential oil — Collins et al 1996

Constituent%
Isomenthone4.6–29.1%
(+)-Limonene11.6–28.2%
Diosphenol12.0–26.3%
Menthone2.5–25.0%
ψ-Diosphenol10.3–23.3%
8-Mercapto-p-menthan-3-one (cis + trans)0.7–6.6%
α-Pulegone [(E)- + (Z)-]0.4–4.6%
(1S)-(–)-β-Pulegone0.6–4.5%
1,8-Cineoletr–4.4%
β-Myrcene0.2–2.8%
Sabinenetr–1.2%

Total pulegone: α + β = ~9.1% max (signature safety-driver).

Chemistry insights

  • Diosphenol + ψ-diosphenol 22.3–49.6% combined — namesake constituents giving the minty-herbal-cassis-black-currant signature. Structurally related to carvone + pulegone (p-menthane scaffold). Responsible for main olfactive character.
  • Pulegone ~9.1% — key hepatotoxic constituent. Metabolized to pulegone epoxide (electrophilic, glutathione-depleting, menthofuran-linked liver injury). T&Y + CEFS class pulegone as hepatotoxic + fetotoxic. Dermal absorption rate sets the cap.
  • Limonene 11.6–28.2% — the dominant monoterpene; primary oxidation substrate. Autoxidation products (limonene-1,2-oxide, carvone, limonene-hydroperoxides) cause delayed contact allergy. IFRA 2009 explicit: oils rich in limonene require antioxidant at production + short shelf life.
  • Menthone + isomenthone ~30–54% combined — p-menthane ketone class. Menthone is mutagenic in some assays (T&Y Ch.14); low-risk at clinical dermal dilutions but contributes to overall pulegone-family pharmacology.
  • 8-Mercapto-p-menthan-3-one (cis + trans) 0.7–6.6% — organosulfur thiol class. Signature "cassis / black-currant / cat-urinary" nuance (also found in [[blackcurrant-bud]]). Very odor-active (threshold ppt range). Unusual thiol chemistry in Rutaceae.
Công Dụng Trị Liệu Chi Tiết
§10 Therapeutic Uses — skin, emotional, physical, respiratory
  • Traditional (South African): Khoisan + Cape settler medicine — diuretic, antiseptic, "kidney/bladder" tonic (leaf decoction, not EO).
  • Aromatherapy: Limited by toxicity concerns. Historical reference suggests urinary-antiseptic claims but clinical data lacking.
  • Flavoring (historic): Gin botanical + flavoring for cassis liqueurs (black-currant flavor from thiols). Modern use regulated (pulegone food restrictions — UK/EC 25 mg/kg food).
  • Perfumery: Primary commercial use — cassis + minty-herbal + gin-accord fragrances.
Năng Lượng & Ngũ Hành
§11 Energetics — TCM, Ayurveda, aromatic energetics
  • Five-element: Thuỷ-Mộc (Water–Wood — urinary-bladder + herbal-minty affinity in traditional Khoisan + Cape settler medicine).
  • Mojay: Not in standard Mojay materia medica (South African endemic, limited Western aromatherapy literature).
  • Cooling, dispersing, diuretic-oriented — menthone/pulegone class energetics; caution due to pulegone pharmacology.

Dữ Liệu Kỹ Thuật Y Khoa

§14 Renderer Contract — Tisserand & Young V2.2

Thông Số Định Lượng

hazards
["hepatotoxic_low","skin_sensitization_if_oxidized"]
phototoxic
false
safety_level
caution
cap_derivation
ty_pulegone_9p1pct_derived
oxidation_risk
medium_high
drug_interactions
[]
shelf_life_months
12
max_dilution_adult
11
contraindicated_all
false
max_dilution_elderly
3
max_oral_dose_mg_day
384
max_dilution_child_2_6
1
max_dilution_sensitive
2
max_dilution_adult_face
3
max_dilution_child_6_12
2
contraindicated_children
false
contraindicated_pregnancy
true
max_dilution_child_under2
0.5
max_dilution_pregnancy_1st
max_dilution_pregnancy_2nd
max_dilution_pregnancy_3rd

Tài Liệu Y Khoa Tham Khảo

  • Tisserand & Young (2014) Essential Oil Safety 2nd ed — Ch.13 p.482–483 (Buchu diosphenol CT) + Ch.14 β-Pulegone + (+)-Limonene profiles
  • Collins, N. F. et al (1996) — chemistry profile (A. betulina + A. crenulata)
  • Anon (1992b) — CEFS pulegone TDI 0.1 mg/kg (pulegone + menthofuran combined)
  • IFRA (2009) — limonene-rich oil antioxidant + shelf-life guidance
  • Bradley, P. R. (1992) — British Herbal Compendium pregnancy contraindication for buchu leaves
  • Burfield, T. (2003) — monoterpene sulfide adulteration documentation