SYMELab
Trang chủThư Viện HươngAngelica Root Himalayan
The Perfumer's Grimoire

Tinh dầu Bạch chỉ Himalaya

Angelica Root Himalayan

Angelica glauca Edgew.

MiddleThảo mộc

“Rễ cần dại ấm ướt sâu lắng, dược thảo trầm tĩnh như lòng đất rừng, thảo mộc nhẹ nhàng mà ám ảnh, như sàn rừng sau mưa thu, vững chãi và an nhiên”

Chân dung Hương

Sáu trục định hình cá tính khứu giác của tinh chất này.

Mang tinh chất này vào sáng tạo của bạn

Đưa tinh chất vào bàn pha chế thủ công hoặc để AI Perfumer dệt nên một công thức hương đồng hành cùng nó.

Mở khoá Pha Chế PremiumMở khoá AI Perfumer

Tóm Tắt Khoa Học

Từ Thư Viện Kinh Điển
  1. Angelica glauca Edgew., Apiaceae. Source: root; steam distillation. "Himalayan Angelica / Chora / Gandrayan / Smooth Angelica / Bạch chỉ Himalaya". COMPLETELY DIFFERENT CHEMISTRY from [[angelica-root]] (European A. archangelica) — this is a phthalide-dominant CNS-active oil, NOT a furanocoumarin-phototoxic oil. Indian traditional herbal medicine heritage (Garhwal + Kumaon Himalayan regions).
  2. Chemistry (Mathela 1988; Kapahi 1991 — via B216): (Z)-3-Butylidene phthalide 11.3–20.5% + (Z)-Ligustilide 8.2–17.4% + β-Phellandrene 5.1–14.2% + α-Pinene 4.3–11.8% + (Z)-3-Butylidene-4,5-dihydrophthalide 3.1–9.5% + Myrcene 2.0–7.1% + Sabinene 1.2–5.8% + p-Cymene 0.8–4.2% + δ-3-Carene 0.5–3.5% + Senkyunolide 0.4–2.8%. Phthalide-dominant (combined phthalides ≈25–50%).
  3. Hazards: CNS depression at high doses; theoretical drug interactions (CNS-sedative synergy); possible emmenagogue (folk). Contraindications: Pregnancy (all trimesters, all routes — folk + phthalide); children <6y. Max dermal: No T&Y numeric cap — framework 2–3% (phthalide CNS signal). Max oral: Framework ~30 mg/day conservative.
  4. Phthalide-CNS-active rail (CRITICAL — distinct from A. archangelica): Butylidene phthalide + ligustilide are CNS-active sedative-anxiolytic phthalide lactones — same chemistry family as Angelica sinensis (Dong Quai — ligustilide is the signature Dong Quai active) + Ligusticum chuanxiong (Chuan Xiong). Mechanism: GABA-A modulation + calcium channel modulation + smooth muscle relaxation. Sedative-hypnotic additive with alcohol + benzodiazepines + opioids + other CNS depressants. Traditional use for anxiety, insomnia, dysmenorrhea — consistent with mechanism.
  5. Species-confusion with A. archangelica rail (CRITICAL): Both are called "Angelica root oil" commercially but they are radically different products — European archangelica is furanocoumarin-phototoxic + CYP3A4 inhibitor; Himalayan glauca is phthalide-CNS-sedative + possible emmenagogue. NEVER substitute one for the other. Furanocoumarin content in A. glauca is negligible; phthalide content in A. archangelica is negligible. If CoA shows phthalides dominant = glauca; if furanocoumarins dominant = archangelica; if BOTH shown, the oil is suspicious (possible blend / adulteration).
🌿
Thận trọngNốt MiddleCelery-herbaceous

Angelica Root Himalayan

Tinh dầu Bạch chỉ Himalaya (Chora / Gandrayan)

Angelica glauca Edgew.

Tinh dầu Bạch chỉ Himalaya (Chora / Gandrayan) — Celery-herbaceous

⚠️Tinh dầu này cần thận trọng khi sử dụng. Đọc kỹ hướng dẫn an toàn.

Tổng Quan

Danh pháp khoa học
Angelica glauca Edgew.
Họ thực vật
Apiaceae
Bộ phận dùng
—
Phương pháp chiết xuất
steam_distillation
Màu sắc
—
Phân loại nốt hương
Nốt Middle
Hương thơm
—
Chemotype / Cultivar
—

Tình trạng tại Việt Nam

Xem chi tiết

Phân loại nốt
Middle
Cường độ
3/5
Độ bền trên da
2–4 giờ
Họ hương
Celery-herbaceous
Hương đầu (Opening)(0–15 phút)

warm damp celery-root, medicinal earthiness with quiet depth, softly herbal and musky, old forest floor after autumn rain, grounding and still

Hương giữa (Heart)(15–60 phút)

Rễ cần dại ấm ướt sâu lắng, dược thảo trầm tĩnh như lòng đất rừng, thảo mộc nhẹ nhàng mà ám ảnh, như sàn rừng sau mưa thu, vững chãi và an nhiên

Hương nền (Drydown)(1–4 giờ)

2–4 giờ

Cường độ hương
3/5
Da khô
2/5

Da dầu/mụn
2/5

Da lão hóa
2/5

Da thường
3/5

Da nhạy cảm
1/5

Da hỗn hợp
2/5

Nhập khẩuImported

Tên gọi tại Việt Nam

Tinh dầu Bạch chỉ Himalaya (Chora / Gandrayan)

Pha Chế & Hòa Hợp

Anxiolytic / Nervine sedative

(Z)-ligustilide and related phthalides modulate GABAergic and serotonergic pathways, producing calming and mild sedative effects consistent with the Angelica phthalide class.

Ref: Pang et al. (ligustilide pharmacology, class-extrapolation from A. sinensis research line); B216 Ch.14 phthalide profile composite

Antispasmodic

Phthalide constituents including butylidenephthalide and (Z)-ligustilide relax smooth muscle via calcium-channel antagonism, reducing visceral and musculoskeletal spasm.

Ref: B216 Ch.14 phthalide profile (celery + lovage + angelica glauca + chuan xiong composite)

Carminative / Digestive tonic

Traditional Ayurvedic application of Chora/Gandrali root for flatulence, gastric discomfort, and digestive atony is supported by the antispasmodic phthalide chemistry of the root EO.

Ref: Ayurvedic Pharmacopoeia of India, Chora/Gandrali monograph; Tisserand & Young 2014, Ch.13 p.441

Emmenagogue / Uterotonic — HAZARD (basis for pregnancy CI)

(Z)-ligustilide exerts uterotonic activity via oxytocin-receptor sensitisation in uterine smooth muscle, constituting the pharmacological basis for the absolute pregnancy contraindication.

Ref: Pang et al. (ligustilide uterotonic mechanism, A. sinensis research line); Ayurvedic Pharmacopoeia of India (classical pregnancy CI for Chora)

Analgesic / Anti-inflammatory

Phthalide constituents attenuate pro-inflammatory mediators and modulate nociceptive signalling pathways; evidence extrapolated from celery seed and lovage root phthalide class peers.

Ref: class-extrapolation from lovage-root and celery-seed EO peers; B216 Ch.14 phthalide profile composite

Grounding / Adaptogenic tonic (traditional)

Himalayan Ayurvedic tradition classifies Gandrayan root as a vata-balancing nervine tonic for fatigue and nervous exhaustion; no constituent-level mechanistic confirmation specific to A. glauca.

Ref: Ayurvedic Pharmacopoeia of India, Chora/Gandrali monograph

AI-summary

No RCT-grade clinical evidence is available specifically for Angelica glauca essential oil. GC composition is characterised by Mathela (1988) and Kapahi (1991), confirming the phthalide chemotype shared with the broader Angelica genus. The primary pharmacological evidence for the dominant phthalide constituent (Z)-ligustilide derives from the A. sinensis research line (Pang et al.), where anxiolytic, antispasmodic, and uterotonic actions have been demonstrated in vitro and in rodent models. The Ayurvedic Pharmacopoeia of India documents classical Chora/Gandrali use for digestive, nervine, and analgesic indications with a traditional-use evidence grade. All therapeutic efficacy claims are traditional-use or class-extrapolation grade (rating ≤ 3); no controlled human studies on A. glauca EO were located in available citations.

Narrative

Tâm trạng: Calming, Grounding

anxietynervous tensionexhaustiongroundlessnessinner stillnessmelancholy

Chakra

root

Ngũ hành

tho

Phương phápLiều lượngGhi chú
Diffusion3-5 drops in 100ml water (ultrasonic) or 2-3 drops on diffuser padMùi đất ấm, cam thảo nhẹ — phù hợp buổi tối để thư giãn hệ thần kinh. Ventilate after 30–40 min. Do not diffuse around pregnant persons, infants, or young children.
Topical massage1.5–2.5% in carrier oil (adult dermal max 2.5%)Lower back, abdomen (non-pregnant adults), or limbs only. Avoid face. CI: pregnancy, children <12. Carrier: sweet almond or fractionated coconut.
Warm compress4–6 drops in 500ml warm water; soak cloth and applyHỗ trợ tiêu hoá hoặc giảm căng cơ. Adults only. Replace compress every 10–15 min. Avoid broken or inflamed skin.
Personal inhaler / Direct inhalation2–3 drops on inhaler wick or clothShort-duration inhalation (1–2 min) for calming nervous tension or mental fatigue. Do not share inhaler with pregnant persons or children.

Dầu nền phù hợp

JojobaWax-ester stability extends shelf life of the phthalide-rich EO and provides a non-greasy, skin-compatible base well-suited to therapeutic massage concentrations.
Sweet almond oilLight texture and near-neutral scent preserve the earthy-balsamic aromatic character; oleic acid profile supports dermal absorption at the 1.5–2.5% working range.
Fractionated coconut oilHighly stable, odourless, and rapidly absorbed — preferred when a clean-finish formulation is needed without masking the EO's distinctive aromatic profile.

Kết hợp tốt với

WoodySpicyResinousHerbaceousGreen

Blend kinh điển

—
—
—
—
[Tisserand & Young] Ch.13 p.441
[Mathela] A. glauca GC composition [via B216]
[IUCN Red List] Angelica glauca vulnerable status (Indian Himalayan Region)
[Indian Himalayan Region Red List] over-harvested medicinal plant
[Ayurvedic Pharmacopoeia of India] Chora / Gandrali monograph (classical use + pregnancy CI)
[Pang et al.] extrapolated from A. sinensis research line)

An Toàn

Giới hạn da tối đa

Xem chi tiết

Giới hạn IFRA

Xem chi tiết

Thai kỳ & Cho con bú

Tam cá nguyệt 1Unknown
Tam cá nguyệt 2Unknown
Tam cá nguyệt 3Unknown

Giới hạn độ tuổi

Xem chi tiết

Bảo quản

Bảo quản nơi tối, mát

Xem hồ sơ an toàn chi tiết

Thông tin chỉ mang tính tham khảo, không thay thế tư vấn y tế chuyên nghiệp. SYMELab v2.0

Bí quyết Phối trộn

Mở khoá Premium để xem những cặp đôi cổ điển và nguyên liệu có ái lực hương với tinh chất này.

Nâng cấp Premium để mở khoá

Thông số Kỹ thuật & An toàn

Mở khoá Premium để xem giới hạn pha loãng, chống chỉ định, tương tác thuốc và tiêu chuẩn chất lượng.

Nâng cấp Premium để mở khoá

Đọc Thêm Chuyên Sâu

Nội dung biên dịch từ tài liệu gốc — mở rộng mỗi mục để xem chi tiết.

Hồ Sơ Hoá Học Chi Tiết
§3 Chemical Profile — chemotype, constituent ranges, adulteration
Constituent%
(Z)-3-Butylidene phthalide11.3–20.5%
(Z)-Ligustilide8.2–17.4%
β-Phellandrene5.1–14.2%
α-Pinene4.3–11.8%
(Z)-3-Butylidene-4,5-dihydrophthalide3.1–9.5%
Myrcene2.0–7.1%
Sabinene1.2–5.8%
p-Cymene0.8–4.2%
δ-3-Carene0.5–3.5%
Senkyunolide0.4–2.8%
Total phthalides combined≈25–50%
Furanocoumarinstrace / negligible

Chemistry insight:

  • Phthalide-dominant — butylidene phthalide + ligustilide + dihydrophthalide + senkyunolide combined ≈25–50%. This is the defining chemistry of A. glauca + A. sinensis + Ligusticum genus — a small but biologically potent family of C₁₂ aromatic lactones with known CNS + smooth-muscle activity.
  • Ligustilide 8–17% is the signature constituent shared with Dong Quai (A. sinensis). Ligustilide demonstrates documented anxiolytic + antispasmodic + neuroprotective activity in animal + cell-culture studies (TCM research). Susceptible to autoxidation → dimers (levistolide A, tokinolide B) which have distinct biological profiles.
  • Butylidene phthalide 11–21% — primary CNS-sedative + smooth-muscle relaxant phthalide. Mechanism includes GABA-A positive allosteric modulation + L-type calcium channel inhibition. Clinically relevant at oral doses; minimal dermal systemic exposure.
  • β-Phellandrene + α-pinene + monoterpene backbone 15–30% — standard Apiaceae monoterpene frame but lower % than A. archangelica (60-80%). Gives a lighter, less resinous character.
  • Furanocoumarins essentially ABSENT / trace — this is the key differentiator from A. archangelica. NOT phototoxic. NOT CYP3A4 mechanism-based inhibitor.
  • Quality / adulteration: Common adulterants: (1) A. sinensis root oil (Chinese Dong Quai — chemistry is very similar; GC differentiation requires careful stereochemistry + trace-marker analysis); (2) Ligusticum chuanxiong oil (Chuan Xiong — also phthalide-dominant, even closer chemistry); (3) synthetic butylidene phthalide + ligustilide blends; (4) dilution with odorless carrier. Authentication requires GC + known-marker fingerprint. Wild-harvested vs cultivated is a sustainability concern, not a chemistry concern.
Công Dụng Trị Liệu Chi Tiết
§10 Therapeutic Uses — skin, emotional, physical, respiratory
  • Emotional / anxiolytic (inhalation + dermal): 1–2% dilution for anxiety, restlessness, insomnia. Supported by Ayurvedic + emerging research on ligustilide-class anxiolysis.
  • Digestive (oral, controlled dose): Ayurvedic Chora tradition for dyspepsia, flatulence, colic. Framework oral ≤30 mg/day.
  • Menstrual support (DERMAL ONLY for non-pregnant adult): 2% abdominal application for dysmenorrhea, irregular cycles. DO NOT USE during pregnancy.
  • Respiratory (inhalation): Traditional use for cough + bronchitis; secondary to digestive + nervous-system uses.
  • Perfumery: 0.1–0.5% for celery-lovage-musk accords.
Năng Lượng & Ngũ Hành
§11 Energetics — TCM, Ayurveda, aromatic energetics
  • Five-element: Thổ (Earth — digestive Spleen-Stomach) + Mộc (Wood — Liver-channel smooth-muscle + emmenagogue) + trace Thủy (Water — Kidney root-energy).
  • Ayurveda: Chora / Gandrali — uṣṇa (hot, warming) + tīkṣṇa (penetrating) + pitta-vāta pacifying at controlled doses; contraindicated in pregnancy per classical texts.
  • Himalayan folk heritage: Garhwali + Kumaoni traditional medicine system; used as digestive tonic + respiratory support + menstrual regulator; also incense + ritual use.

Dữ Liệu Kỹ Thuật Y Khoa

§14 Renderer Contract — Tisserand & Young V2.2

Thông Số Định Lượng

hazards
["CNS_depression_phthalide_high_oral_dose","uterotonic_pregnancy","ligustilide_autoxidation_shelf_life"]
phototoxic
false
plant_part
root
iucn_status
vulnerable
cites_status
not_listed_but_IUCN_vulnerable
cyp_inhibition
[]
chemistry_class
phthalide_dominant_CNS_sedative
drug_interactions
["CNS_sedative_additive_benzodiazepines_opioids_alcohol_antihistamines_Z_hypnotics"]
photoallergy_risk
—
shelf_life_months
30
sustainability_risk
high_Himalayan_over_harvested
dominant_constituent
butylidene_phthalide_plus_ligustilide
max_dilution_elderly
1.5
max_oral_dose_mg_day
30
furanocoumarin_content
trace_or_absent
max_dilution_child_2_6
0
antioxidant_recommended
true
max_dilution_adult_face
1.5
max_dilution_child_6_12
0.5
acute_oral_ld50_rat_g_kg
4
contraindicated_pregnancy
true
max_dilution_child_under2
0
total_phthalide_pct_range
["25","50"]
max_dilution_adult_general
2.5
max_dilution_breastfeeding
1
max_dilution_pregnancy_1st
0
max_dilution_pregnancy_2nd
0
max_dilution_pregnancy_3rd
0
acute_dermal_ld50_rabbit_g_kg
—
contraindicated_breastfeeding
false
max_oral_dose_mg_day_pregnancy
0
contraindicated_children_under2
true

Luận Giải Văn Cảnh

latin_name

Angelica glauca Edgew.

phototoxic

iucn_status

vulnerable

cites_status

not_listed_but_IUCN_vulnerable

cyp_inhibition

[] (no significant CYP inhibition — distinct from A

chemistry_class

phthalide_dominant_CNS_sedative_apiaceae_root

sourcing_caution

prefer_cooperative_cultivated_avoid_opportunistic_wild_harvest

drug_interactions

CNS_sedative_additive_GABA_modulationbenzodiazepinesopioidsalcoholsedating_antihistaminesZ_hypnotics

known_adulterants

angelica_sinensis_oil_Dong_Quailigusticum_chuanxiong_oil_Chuan_Xiongsynthetic_phthalide_blendsneutral_carrier_dilution

shelf_life_months

30

pregnancy_mechanism

emmenagogue_folk_plus_phthalide_uterotonic_ligustilide_documented_in_sinensis

safety_determinants

specieschemotypeplant_partextraction_method

sustainability_risk

high_over_harvested_wild_collection_Himalayan_red_list

autoxidation_concern

ligustilide_dimerization_to_levistolide_A_and_tokinolide_B

dominant_constituent

butylidene_phthalide_plus_ligustilide

dermal_cap_derivation

framework_CNS_phthalide_signal_no_T&Y_numeric_published

uv_avoidance_required

furanocoumarin_content

trace_or_absent

antioxidant_recommended

authentication_requires

full_GC_MS_plus_origin_documentation

contraindicated_pregnancy

phthalide_cluster_species

angelica_glauca_this_pageangelica_sinensis_dong_quai_NOT_EOligusticum_chuanxiong_chuan_xionglevisticum_officinale_lovage

total_phthalide_pct_range

2550

max_dilution_adult_general

2

contraindicated_pregnancy_t1

contraindicated_pregnancy_t2

contraindicated_pregnancy_t3

genus_level_safety_inheritance

family_level_safety_inheritance

species_disambiguation_from_archangelica

completely_different_chemistry_and_hazard_profile

commercial_adulterant_risk_from_sinensis_or_chuanxiong

Tài Liệu Y Khoa Tham Khảo

  • Tisserand & Young (2014) Essential Oil Safety 2nd ed — Ch.13 p.441
  • Mathela (1988); Kapahi (1991) — A. glauca GC composition [via B216]
  • Ch.14 Phthalide profile (celery + lovage + angelica glauca + chuan xiong composite) [via B216]
  • IUCN Red List — Angelica glauca vulnerable status (Indian Himalayan Region)
  • Indian Himalayan Region Red List — over-harvested medicinal plant
  • Ayurvedic Pharmacopoeia of India — Chora / Gandrali monograph (classical use + pregnancy CI)
  • Pang et al. (ligustilide pharmacology, anxiolytic + uterotonic mechanism — extrapolated from A. sinensis research line)